Lhou gherigs disease
Physical exercise or therapy can give patients independence. Using both animal models and cell culture systems, scientists are trying to determine how and why ALS-causing gene mutations lead to the destruction of neurons.
ALS is a motor neuron disease , also spelled "motor neurone disease", which is a group of neurological disorders that selectively affect motor neurons , the cells that control voluntary muscles of the body. Although it is still not clear how mutations in the SOD1 gene lead to motor neuron degeneration, there is increasing evidence that the gene playing a role in producing mutant SOD1 protein can become toxic. Another drug, Nuedexta, was approved by the FDA in for the treatment of involuntary crying or laughter, called Pseudobulbar Affect. In ALS, both the upper motor neurons and the lower motor neurons degenerate or die, and stop sending messages to the muscles. Currently, there is no cure for ALS and no effective treatment to halt, or reverse, the progression of the disease. It's unclear what about military service might trigger the development of ALS. It can extend also the time before a patient must go on a ventilator. Military service. Hospice care can improve symptom management at the end of life and increases the likelihood of a peaceful death. The illness can cause symptoms similar to other diseases that affect nerves and muscles, including Parkinson's disease and stroke. Other early signs are tripping or falling a lot, dropping things, having difficulty speaking, and cramping or twitching of the muscles. You might need a device to help you breathe at night, similar to what someone with sleep apnea might wear. Other presenting symptoms include trouble swallowing or breathing, cramping, or stiffness of affected muscles; muscle weakness affecting an arm or a leg; or slurred and nasal speech. As many as 30, Americans have the disease at any given time.
This eventually affects chewing, swallowing, speaking and breathing. Most people eventually are not able to walk or use their hands and arms, lose the ability to speak and swallow food and their own saliva, and begin to lose the ability to cough and to breathe on their own.
In the United States, as many as 20, to 30, people have the disease, and about 5, people are diagnosed with it each year, according to the Centers for Disease Control and Prevention CDC. These teams can design an individualized treatment plan and provide special equipment aimed at keeping people as mobile, comfortable, and independent as possible.
Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. Much study has been done, but no single agent or chemical has been consistently associated with ALS.
Lou gehrigs disease wiki
Range of motion and stretching exercises can help prevent painful spasticity and shortening contracture of muscles. Hospice care can improve symptom management at the end of life and increases the likelihood of a peaceful death. Regardless of where the symptoms first appear, muscle weakness and atrophy spread to other parts of the body as the disease progresses. It affects people of all races and ethnic backgrounds. The mission of the National Institute of Neurological Disorders and Stroke NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. French neurologist Jean-Martin Charcot discovered the disease in Riluzole is believed to reduce damage to motor neurons by decreasing levels of glutamate, which transports messages between nerve cells and motor neurons.
Riluzole, a drug that modestly prolongs survival in ALS, inhibits glutamate release from pre-synaptic neurons; however, it is unclear if this mechanism is responsible for its therapeutic effect.
Treatments for the disease are limited, but promising research is ongoing.
This work involves tests of drug-like compounds, gene therapy approaches, antibodies, and cell-based therapies.
based on 106 review